Originally, atypical antipsychotics were drugs that did not produce catalepsy (Immobility) in animal models. Unlike typical antipsychotics (neuroleptics), atypical antipsychotics decreased amphetamine induced hyperactivity in rats in doses that did not produce catalepsy.
Classically, an antipsychotic is said to be atypical when it improves both positive and negative symptoms of schizophrenia but
Classically, an antipsychotic is said to be atypical when it improves both positive and negative symptoms of schizophrenia but
- Produces minimal or no EPS
- Causes minimal or no sustained prolactin elevation
Many researchers have proposed greater efficacy in treating negative symptoms, mood changes and cognitive deficits, giving rise to broader definitions of atypicality.
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